Re: [ ::: ♥Keep_Mailing♥ ::: ]™ Amazing Anti-Ageing Drug

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2015-12-19 11:57 GMT+08:00 'DR. MAHESH' via Keep_Mailing <keep_mailing@googlegroups.com>:

AMAZING ANTI-AGEING DRUG

Can you imagine living a healthy life well into your 120s? That could be a reality sooner rather than later, after the US Food and Drug Administration recently gave the go-ahead for clinical trials to be conducted on the world's first anti-aging drug.

The drug, called metformin, has already been proven to extend animal lifespans, and the FDA has resultantly decided that trials should be conducted to see if it has the same effect on humans. It is already the most widely used drug in the world for treating Type 2 diabetes.

Furthermore, anecdotal evidence was found last year by researchers at Cardiff University, who observed that patients with diabetes taking metformin were living longer than others who were not diabetic, in spite of diabetics having an average life expectancy that's eight years shorter.

Successful clinical trials would mean that 70-year-olds could have the biological health of 50-year-olds. Scientists also believe that stopping aging could eventually consign aging-related diseases, such as Alzheimer's and Parkinson's, to history.

We age because our cells divide themselves in order to keep our bodies in the best state of health, however problems begin to occur the more times cells divide, meaning that damage to our bodies eventually can no longer be repaired.

The theory is that if the aging process is slowed down, then all the diseases and pathology associated with aging can be slowed down as well. Scientists believe that this can be achieved because all of our cells contain a DNA blueprint that could keep our bodies functioning correctly forever.

 

 

Metformin is believed to have life-extending possibilities for humans because of its ability to increase the number of oxygen molecules released into a cell. This process is believed to boost cell robustness and longevity.

 

American scientists are currently looking for 3,000 volunteers aged between 70 and 80 who either have, or are at risk of, cancer, heart disease and dementia, to take part in the clinical trial of metformin, which is scheduled to begin next winter.

According to the World Health Organization, the average global life expectancy currently stands at 71.0 years, but if scientists manage to replicate the results observed in animals during the clinical trials, human lifespan could increase by almost 50%. Amazing!  

Content Source: New Zealand Herald

Is the anti-aging drug metformin the fountain of youth?

Scientists are convinced that the best candidate for anti-aging medicine is metformin. This is an inexpensive and commonly used pharmaceutical for the treatment of diabetes. It works by increasing the amount of oxygen molecules released into the cell, and thus appears to increase longevity in animals. According to a report from the International Business Times, the medicine could allow people to live to between 110 and 120 years without the ailments that accompany those difficult years.

"This would be the most important medical intervention in the modern era, an ability to slow aging," said Dr. Jay Olshansky, a professor in the School of Public Health at the University of Illinois at Chicago.

The World's First Anti-Aging Drug #metformin May Be Closer Than You Think |https://t.co/4ofMfUAejy pic.twitter.com/SVYTPYjl3f

— S.Puts (@sellputs) December 1, 2015

In mice, metformin managed to extend their life by 40 percent, and their bones were stronger with signs that they stayed more youthful for longer too. Last year, Cardiff University reported that in patients taking metformin, they noticed that they live longer than other patients.

"Patients treated with a drug widely prescribed for type 2 diabetes can live longer than people without the condition, a large-scale University-led study involving over 180,000 people has shown," the report reads.

Clinical trials of metformin will start in the U.S. next year. Various institutions are currently recruiting 3,000 volunteers between the ages of 70 and 80, who suffer from cancer, heart disease, or dementia, to take part in the trial. Scientists hope that the trials will prove that metformin can slow the aging process in humans and alleviate or even cure their disease.

"If we can slow ageing in humans, even by just a little bit it would be monumental. People could be older, and feel young. Enough advancements in ageing science have been made to lead us to believe it's plausible, it's possible, it's been done for other species and there is every reason to believe it could be done in us," Olshansky said.

Regarding the findings, co-leader of the study Nir Barzilai, from the Albert Einstein College of Medicine, gave the following statement.

"People on metformin get 30 percent less cancers, almost every cancer except maybe prostate cancer. There are fewer studies, but there is a signal that metformin prevents cognitive decline. Additionally, there is a study that suggests that people on metformin who, when they start taking metformin, are more obese and sicker than people without diabetes, they outlive people without diabetes."

If the same results can be achieved in humans, life expectancy could be increased by up to half. This could give humans extra years that could provide medicines for cancer and lead to possible cures for other deadly and difficult-to-treat diseases.

Nir Barzilai tells @BBCnews about the #TAME study that seeks to find out the age-slowing potential of #metformin https://t.co/7TJbPcqz0U

— Aging Research (@Aging_Research) December 2, 2015

Aging does not have to be an inevitable process because all cells contain the DNA scheme, which may enable the continuous proper functioning of the body. Every cell in the body carries DNA, so theoretically, the body cannot function properly forever. However, some marine animals do not age. For example, lobsters don't actually get older, and some scientists believe that if left undisturbed, they can't die. And some turtles have even been known to live for more than 200 years.

The average life expectancy of humans in most developed countries is around 80 years. If the upcoming metformin trials are successful, it will mean that a person in their 70s would be as biologically healthy as a 50-year-old. As the Telegraph writes, it could usher in a new era of "geroscience," where doctors would no longer fight individual conditions like cancer, diabetes, and dementia, but instead treat the underlying mechanism – aging.

Researchers say that the drug #metformin could become the world's first anti-aging drug https://t.co/DizAWnMpeO pic.twitter.com/LsUxnO2Hh1

— Hopkins Nursing (@JHUNursing) December 2, 2015

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