Keep Mailing: [ ::: ♥Keep_Mailing♥ ::: ]™ Grapefruit Juice Can Lead to Severe Poisoning

The Potential Risk of Grapefruit Juice

Citrus fruits are considered to be very healthy, thanks to their high vitamin C content as well as the many minerals and other nutrients they contain. However, ingesting grapefruit juice can lead to severe poisoning when mixed with certain substances. A variety of medical studies in recent years found that combining grapefruit juice with certain medications can lead to an overdose. This article will discuss the reasons for these results, and list the medications you absolutely cannot mix with grapefruit.

The Grapefruit/Medication Connection

The human body produces an enzyme called CYO3A4 that, amongst other things, helps break down certain chemicals before they are absorbed into the bloodstream. Grapefruits contain a chemical that inhibits the CYO3A4 enzyme's functions, which leads to more of the medication being absorbed into the bloodstream. When the level of medication in the blood is too high, you enter a state of overdose, which can lead to exacerbated side-effects and even poisoning.

Other Citrus Fruits

The inhibiting chemical in grapefruit can also be found in other citrus fruits, such as pomelo, limes, and bitter oranges (a type of orange that is very bitter and is mainly used in jams). It's important to mention that other species of oranges, as well as lemons - are safe to ingest, as they don't contain the aforementioned chemical.

Potential Severity of Reactions

It's difficult to predict the severity of reaction grapefruit juice will have on one's body, as it can be affected by many variables. Different juices contain different levels of the inhibiting chemical, meaning that each type of juice can have a different level of effect. Additionally, the quantity of juice consumed can have a drastically varied effect according to one's weight.

Medications that Should Not Be Taken with Grapefruit Juice:

There are currently more than 85 different medications that should not be taken with grapefruit juice, and new drugs join the list every year. The following list shows the drugs that pose the most danger when taken with Grapefruit:

Heart Rate and Blood Pressure Medication
Generic name	Commercial names
Amlodipine	Norvasc
Amiodarone	Procor, Amiodacore, Amiocor
Felodipine	Logimax, Penedil
Nifedipine	Osmo-Adalat, Nifedipine-Teva, Pressolat, Megalat
Nimodipine	Nimotop
Quinidin	Quiniduran
Verapamil	Verapress, Apoacor, Ikacor, Ikapress, Veracor
Lipid Lowering Medication
Generic name	Commercial names
Atorvastatin	Lipitor
Lovastatin	Lovalip
Simvastatin	Simovil, Simvacor, Simvastatin-Teva
Tranquilizers and Psychiatric Medication
Generic name	Commercial names
Buspirone	Buspirol, Sorbon
Clomipramine	Anafranil, Maronil
Diazepam	Assival, Diaz, Valium
Midazolam	Dormicum, Midazol, Midazolam
Pimozide	Orap Forte
Sertraline	Lustral
Other (Immunosuppressants, antihistamines, etc.)
Generic name	Commercial names
Carbamazepine	Carbi, Tegretol, Teril, Timonil
Cisapride	Prepulsid
Cyclosporine	Sangcya, Sandimmun, Deximune
Itraconazole	Sporanox
Saquinavir	Invirase, Fortovase
Sirolimus	Rapamune
Tacrolimus	Prograf

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Posted by: Vue DeDiue <vueddieu@gmail.com>

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